Monday, July 25, 2011
• Remura (Ista Pharmaceuticals, Irvine, Calif.) Remura is lowdose bromfenac, a non-steroidal anti-inflammatory drug; it’s currently available in Xibrom ophthalmic solution as a treatment for postoperative inflammation following cataract surgery. (Twice-daily Xibrom will be replaced by the newly approved oncea- day bromfenac product Bromday during the next few months.) Phase III trials of low-dose bromfenac as a treatment for dry eye are under way as of September 2010. Ista plans to conduct four randomized, doublemasked, placebo-controlled studies under a special protocol assessment agreed upon with the Food and Drug Administration; the studies will involve more than 30 sites in the United States. Two concentrations of bromfenac will be tested (both lower than Xibrom’s 0.09% concentration). To meet FDA guidance on drugs for chronic dosing, the company expects to conduct both a six-month and a 12-month safety study. According to the Ista website, the company hopes to report efficacy results by mid-2011.
Friday, July 22, 2011
I have always been interested in the treatment of dry eye. Over the years I have tried pretty much everything that has come along. I have tried artificial tears, steroids, Restasis, Azasite, Lacriserts. Lately I have been using some non-steroidal anti-inflammatory medications topically.
Actually getting excellent results. Hope to continue to help patients feel better with this really common condition.